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KMID : 1037120150330020073
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The World Journal of Men′s Health
2015 Volume.33 No. 2 p.73 ~ p.80
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Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats
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Bae Woong-Jin
Ha U-Syn
Choi Jin-Bong
Kim Kang-Sup
Youn Moon-Yeon
Cho Hyuk-Jin
Hong Sung-Hoo
Lee Ji-Youl
Wang Zhiping
Hwang Sung-Yeoun
Kim Sae-Woong
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Abstract
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Purpose: We investigated the protective effects of the herbal formulation KH-204 in the bladder of androgen-deprived rats.
Materials and Methods: Male rats aged eight weeks were randomly divided into four groups, containing eight rats each: sham operation only (normal control group), androgen-deprived only (androgen-deprived control group), and androgen-deprived followed by treatment with 200 mg/kg or 400 mg/kg of KH-204. After 0.5 mg/kg of leuprorelin was subcutaneously injected in the androgen-deprived groups, the oral administration of either distilled water in the two control groups or KH-204 in the treatment group was continued for four weeks. Serum testosterone levels, RhoGEF levels, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, oxidative stress, and histologic changes were evaluated after treatment.
Results: Treatment with the herbal formulation KH-204 (1) increased serum testosterone levels; (2) restored the expression of RhoGEFs, endothelial NO synthase, and neuronal NO synthase; (3) increased the expression of superoxide dismutase; and (4) decreased bladder fibrosis.
Conclusions: Our results suggest that the positive effects of KH-204 on the urinary bladder may be attributed to its antioxidant effects or to an elevation in NO-cGMP activity.
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KEYWORD
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Antioxidants, Hypogonadism, Phytotherapy, Testosterone, Urinary bladder
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